|
KMID : 1094720220270030407
|
|
Biotechnology and Bioprocess Engineering
2022 Volume.27 No. 3 p.407 ~ p.414
|
|
|
Attenuation of Psoriasis Symptoms Following Treatment with C-phycocyanin from Spirulina Maxima in a Mouse Model
|
|
Jang Jin-Young
Lee Byung-Man
Jun Sang-Yoon
Yang Yun-Jung
Shin Hwa-Sung
|
|
|
Abstract
|
|
|
|
Psoriasis is a chronic autoimmune disease caused by an abnormal proliferation of keratinocytes in the epidermis. The efficacy of C-Phycocyanin, a photosynthetic pigment isolated from Spirulina Maxima, was assessed via histological examinations, and anti-inflammatory properties were investigated in mouse models of imiquimod-induced psoriasis (BALB/C-nu and BALB/C). C-phycocyanin lowered epidermal thickening, as well as immune cell clustering in the dermis. Furthermore, C-phycocyanin modulated the levels of inflammatory cytokines (tumor necrosis factor-α, interleukin [IL]-6, cyclooxygenase-2, IL-1b) in the BALB/C-nu mouse model and psoriasis-related cytokines (IL-17a, interferon-gamma, calcitonin gene-related peptide) in BALB/c mice. We show that C-phycocyanin could be developed as a natural pharmaceutical against psoriasis.
|
|
|
KEYWORD
|
|
|
psoriasis, C-phycocyanin, Spirulina Maxima, animal test, anti-inflammation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|